Blar i forfatter "Forsdahl, Guro"

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    • Detection of DHCMT long-term metabolite glucuronides with LC-MSMS as an alternative approach to conventional GC-MSMS analysis 

      Göschl, Lorenz; Gmeiner, Günter; Gärtner, Peter; Steinacher, Michael; Forsdahl, Guro (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-17)
      Dehydrochloromethyltestosterone (DHCMT) is one of the most detected illicit used anabolic–androgenic steroids in professional sports. Therefore, a fast and accurate analysis of this substance is of great importance for a constructive fight against doping abuse. The conventional method for the analysis of this drug, GC-MSMS, is very sensitive and selective but also very time- and resource-consuming. ...

    • Development and validation of a simple online-SPE method coupled to high-resolution mass spectrometry for the analysis of stanozolol-N-glucuronides in urine samples 

      Göschl, Lorenz; Gmeiner, Günter; Enev, Valentin S; Kratena, Nicolas; Gärtner, Peter; Forsdahl, Guro (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-17)
      Stanozolol is still the most commonly used illicit anabolic‐androgenic steroid (AAS) in professional sports. Therefore, accurate and fast analysis and long detection windows are of great interest in the field of antidoping analysis. In this work, a very simple, fast, and highly sensitive online solid‐phase extraction method coupled with liquid chromatography–high‐resolution tandem mass spectrometry ...

    • Lipidomics in ulcerative colitis reveal alteration in mucosal lipid composition associated with the disease state 

      Diab, Joseph; Hansen, Terkel; Goll, Rasmus; Stenlund, Hans; Ahnlund, Maria; Jensen, Einar; Moritz, Thomas; Florholmen, Jon; Forsdahl, Guro (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-11)
      <p><i>Background - </i>The onset of ulcerative colitis (UC) is associated with alterations in lipid metabolism and a disruption of the balance between pro- and anti-inflammatory molecules. Only a few studies describe the mucosal lipid biosignatures during active UC. Moreover, the dynamics of lipid metabolism in the remission state is poorly defined. Therefore, this study aims to characterize mucosal ...

    • Mucosal Metabolomic Profiling and Pathway Analysis Reveal the Metabolic Signature of Ulcerative Colitis 

      Diab, Joseph; Hansen, Terkel; Goll, Rasmus; Stenlund, Hans; Jensen, Einar; Moritz, Thomas; Florholmen, Jon; Forsdahl, Guro (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-27)
      The onset of ulcerative colitis (UC) is characterized by a dysregulated mucosal immune response triggered by several genetic and environmental factors in the context of host–microbe interaction. This complexity makes UC ideal for metabolomic studies to unravel the disease pathobiology and to improve the patient stratification strategies. This study aims to explore the mucosal metabolomic profile in ...

    • Quantification of endogenous steroid sulfates and glucuronides in human urine after intramuscular administration of testosterone esters 

      Forsdahl, Guro; Zanitzer, Katharina; Erceg, Damir; Gmeiner, Günter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-22)
      For an effective detection of doping with pseudo-endogenous anabolic steroids, the urinary steroid profile is of high value. In this work, the aim was to investigate steroid metabolism disruption after exogenous intramuscular administration of different testosterone esters. The investigation focused on both sulfo – and glucoro conjugated androgens. A single intramuscular injection of either 1000 mg ...

    • A Quantitative Analysis of Colonic Mucosal Oxylipins and Endocannabinoids in Treatment-Naïve and Deep Remission Ulcerative Colitis Patients and the Potential Link With Cytokine Gene Expression 

      Diab, Joseph; Al-Mahdi, Rania; Gouveia, Sandra; Hansen, Terkel; Jensen, Einar; Goll, Rasmus; Moritz, Thomas; Florholmen, Jon; Forsdahl, Guro (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-22)
      <p><i>Background</i> - The bioactive metabolites of omega 3 and omega 6 polyunsaturated fatty acids (ω-3 and ω-6) are known as oxylipins and endocannabinoids (eCBs). These lipid metabolites are involved in prompting and resolving the inflammatory response that leads to the onset of inflammatory bowel disease (IBD). This study aims to quantify these bioactive lipids in the colonic mucosa and to ...

    • Stanozolol-N-glucuronide metabolites in human urine samples as suitable targets in terms of routine anti-doping analysis 

      Göschl, Lorenz; Gmeiner, Günter; Gärtner, Peter; Stadler, Georg; Enev, Valentin; Thevis, Mario; Schänzer, Wilhelm; Guddat, Sven; Forsdahl, Guro (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-05)
      The exogenous anabolic-androgenic steroid (AAS) stanozolol stays one of the most detected substances in professional sports. Its detection is a fundamental part of doping analysis, and the analysis of this steroid has been intensively investigated for a long time. This contribution to the detection of stanozolol doping describes for the first time the unambiguous proof for the existence of ...

    • Use of Selective Serotonin Reuptake Inhibitors – Validity of Self-Report versus Plasma Concentrations and Pharmacy Dispensations – A Cross-Sectional Analysis of the Norwegian Women and Cancer Study 

      Waaseth, Marit; Havelkova, Martina; Forsdahl, Guro; Lund, Eiliv; Log, Tomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-30)
      Purpose: To validate self-reported current use of selective serotonin reuptake inhibitors (SSRI) in the Norwegian Women and Cancer study (NOWAC) and to identify factors associated with discordance between data sources.<p> <p>Material and Methods: This is a cross-sectional record-linkage study comparing SSRI-use derived from four data sources: 1) Specific SSRI questions in the main NOWAC questionnaire, ...